Diabetic nephropathy is amongst the major complications that are witnessed by the diabetic population with respect to mortality and morbidity. Though it goes undiagnosed in the initial stages, the symptoms at the later stages include leg and ankle swelling, high blood pressure, morning weakness, vomiting, nausea, increased albumin secretion in urine, BUN (blood urea nitrogen), and itching. Diabetic nephropathy is being treated through ACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin II receptor blockers) render superlative protection to kidney. Ramipril, enalapril, captopril, and Lisinopril are the ACE inhibitors, whereas irbesartan, candesartan, and losartan are the ARBs.

Diabetic gastroparesis does occur in the patients contracting both – type 1 and type 2 diabetes. Females are reported to have this on the higher side. By surgical treatment, diabetic gastroparesis market spans parenteral nutrition, PEG (Percutaneous Endoscopic Gastronomy) kits, and GES (Gastric Electrical Stimulation). Drugs-wise, it’s antiemetic agents, gastroprokinetic agents, and botulinum toxin. By diagnosis, it’s gastric failure (stage 3) and compensated gastroparesis (stage 1 and stage 2).

The life science products include recombinant proteins (immune checkpoint regulators, chemokines, growth factors, cytokines, colony stimulating factors, hormones, enzymes and inhibitors, and others) and cell lines (immunotherapy cell lines, ion channel cell lines, GPCR cell lines, cell signaling pathway cell lines, gene knockout cell lines, cancer cell lines, and others), and antibodies (immune checkpoint antibodies, epitope tag antibodies, isotype control antibodies, primary antibodies, assay antibodies, and others), visible tumor samples, and tumor tissue microarrays. Application-wise, they are toxicity screening, drug discovery and development, basic research, tissue engineering, drug screening, biopharmaceutical production, toxicity screening, and forensic testing.

If diabetes is not controlled, the likelihood of diabetic foot ulcer can’t be ruled out. Coming to diabetic foot ulcer therapeutics, Orpyx Medical Technologies Inc., in December 2019, did come up with Orpyx SI Sensory Insoles facilitating remote patient monitoring to prevent diabetic foot and neuropathy-related ulcers. Also, UPM, in January 2019, did launch new-fangled advanced wound care product all across the Europe. It is known as “FibDex”, which is the first kind of wound dressing made from wood-based nanofibrillar cellulose for receiving regulatory approval and CE-certified.

Diabetic socks are being recommended for reducing risk of injury too foot, increasing blood flow, and retaining dryness of feet. As such, these socks act as anti-fungal, anti-bacterial, and moisture-wicking material. As far as developments are concerned, Siren, in March 2018, announced launching its very first diabetic socks, which could be monitored through smartphone app – like, it could alert regarding signs of “inflammation”. Later, i.e. in October 2019, Handok Pharm entered into collaboration with fashion hosiery brand to launch its new diabetic socks.

There are automated liquid handling (ALH) systems, as the name suggests, programmed for handling liquids and delivering reproducible and precise results. These techniques do play a vital role in research and clinical laboratories. By type, the automated liquid handling market spans multi instrument system, individual benchtop workstation, standalone, and others. Modality-wise, it’s fixed tip and disposable tip. Procedure-wise, it’s serial dilution, PCR setup, high-throughput screening, whole genome amplification, cell culture, plate reformatting, array printing, and others.

Hospital-acquired infections need to be addressed on priority, as chronic patients would be the ones most affected. As such, medical nonwovens and disinfectants are being used at a large-scale within the hospital premises. Also, the number of surgeries is increasing at an alarming rate. When something like Covid-19 springs up, the number of hospitalizations is bound to witness exponentiation. This calls for increase in the demand for hospital acquired infection control. Product wise, control could be exercised through endoscope processors, disinfectors, sterilizers, and disinfectants (hand disinfectants, skin disinfectants, instrument disinfectants, and surface disinfectants/disinfectant robots, disinfectant wipes, disinfectant liquids, and disinfectant sprays).

Urgency with respect to getting rid of human errors (that could prove to be fatal) is the major factor driving the medication dispenser market. Institute of Medicine states that more than 5000 fatalities happen every single year – either through dearth of skilled workforce or negligence on the part of those available. Coming to developments, Innovation Associates has its advanced robotics systems along with scalability in “PharmASSIST ROBOTx” dispensing system.

Physiotherapy is mandatory as a part of post-operative treatment. Also, increase in the number of sports injuries and road mishaps have made physiotherapy indispensable. Application-wise, physiotherapy equipment comprise neurology (spinal cord injuries, stroke, Parkinson’s Disease, Multiple Sclerosis, Cerebral Palsy, and others), musculoskeletal, pediatrics, pulmonary & cardiovascular, and others. By type, it’s cryotherapy, hydrotherapy, CPM (Continuous Passive Motion), ultrasound, electric simulation, heat therapy, therapeutic exercise, and others.

Health Caregiving is also flourishing with increase in the population aged 60 and above. Regarding developments, Seniorlink, Inc. in November 2019, did collaborate with RAND Corporation for conducting research on effectively integrating the family caregivers into patient care teams.

Persistence Market Research (PMR) has profiled the key players as follows:

• Mesoblast Ltd.
• Novartis AG
• ChemoCentryx Inc.
• GenKyoTex S.A.
• Mallinckrodt Pharmaceuticals
• Evoke Pharma
• Salix Pharmaceuticals, Inc.
• Alfa Wassermann SPA
• BPS Bioscience Inc.
• Crown Bioscience Inc.
• Genscript Biotech Corporation
• Bio-Rad Laboratories Inc.
• HomeHero, Inc.
• Cariloop, Inc.
• UnaliWear, Inc.
• Coloplast Corp
• ConvaTec Group Plc
• Handok Pharm
• Siren
• Gilson, Inc.
• Aurora Biomed Inc.
• Eppendorf AG
• Getinge Group
• Sterigenics International LLC
• Innovation Associates
• Omnicell
• Select Medical
• US Physical Therapy, Inc.
• Concentra Operating Corporation
• Kindred Healthcare, Inc.

In a nutshell, Persistence Market Research (PMR) has ruffled the feathers of the chronic ailments like diabetes and entailed the therapeutic measures in its market study.